Sadly enough, I believed in the vets treating him that they had his best interest at heart. ... My older cat who is indoor-outdoor during the summer months has lived with my other 2 indoor cats for a year. I've used mirtazapine for both my cats, one has kidney disease and one has IBD. The problem with oral use in the cat is that the human 15mg tablet cannot easily be cut smaller than into quarters. My cat hasn't been eating lately, so my vet prescribed mirtazapine as an appetite stimulant. They each only had 1/4-1/8 pill every 3-4 days a couple of times (at different times) and then their appetites came back. What killed my cat? He had a large round hole in his stomach. Mirtazapine is an antidepressant when used in people, and it turns out that this drug also possesses appetite-stimulating properties. Cerenia killed my cat. Not long after I gave her her first pill, she was acting really hungry, so I filled up her plate and she ate all of it, something she hasn't done in years. The U.S. Food and Drug Administration (FDA) recently approved Mirataz (mirtazapine transdermal ointment), a new animal drug used to manage undesired weight loss in cats. This effect has been observed in dogs but not in cats. I gave her three servings and she licked the plate clean and went to her bed. VetVine is an accredited Continuing Education provider for veterinary professionals and resource of expert-driven pet health information for pet owners. He lost 4 lbs. I didn't know about its potential to induce serotonin syndrome so I was quite shocked when I checked her symptoms against mirtazapine side effects online. My cat was given 1/4 tab of Mirtazapine yesterday around 2:30 pm, along with 150ml of subQ fluids, as she was dehydrated. A commonly prescribed anti-seizure medication, phenobarbital makes the body produce more CYP enzymes, which increases the clearance and decreases the effectiveness of many types of medications, including digoxin, glucocorticoids, amitriptyline, clomipramine, theophylline, and lidocaine. Gave him some this am about 4 hours ago and now he is restless and calling. It did make both of them pretty vocal. Now my one cat who is just over 1 is a deterrent He was given multiple shots month after month for 6 months. On the label, it says "May cause vocalization or odd behavior." He keeps going to the food dish and eating a few bits, sits for a few minutes, wanders around & vocalizing. The use of mirtazapine as an appetite stimulant in cats has been discussed previously in this Forum, but remains an important topic due to its widespread use in feline medicine. This is the forum topic view page. My cat at the moment is around 12 lbs lost a lot of weight since he has been sick, normally he is around 16lbs not fat just big. Anyway I gave him 1/4 of the … in 1 month. Oral Use in Cats The tablet form can also be used in cats but is given every 1, 2 or 3 days. If mirtazapine does not seem effective for a dog, consider a different product such as capromorelin or cyproheptadine. It is a business. My cat, Saoirse, only ever received one dose of mirtazapine and her pupils were like dinner plates plus she had other quite alarming side effects. And someone, somewhere then had an “Ah Ha moment” wondering if the drug would work as an appetite stimulant in cats, and to be delivered as a transdermal rather than a pill. Vet gave me Mirtazapine instead of Cypro for my 17yr old with IBD & now CRF. He then came down with an aversion to eating and drinking water. by Kim (FL) To make a long story short, he was let outside and found the next day, disemboweled with no blood. No so. 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