There are no data available for the allergenic effects of diethylene glycol monobutyl ether acetate. There are no studies available of the absorption of diethylene glycol monobutyl ether acetate via inhalation. Diethylene glycol monobutyl ether acetate. Cite this entry as: Gooch J.W. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. In a 13‐week study in which diethylene glycol monobutyl ether was administered to rats with the drinking water, no histopathological changes to the sexual organs were detected up to the highest dose used of 1000 mg/kg body weight and day (see © 2021 Eastman Chemical Company or its subsidiaries. DB Acetate (Diethylene Glycol Monobutyl Ether Acetate). In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is also provisionally classified in Pregnancy Risk Group C. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace. Floats and mixes slowly with water. All rights reserved. A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. Nor was diethylene glycol monobutyl ether found to have any mutagenic effects in the available studies (see Eastman™ DB Acetate … The metabolites were determined in the urine. After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. 111-90-0: Ethylene glycol monobutyl ether acetate: Butyl cellosolve acetate… After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. The dermal LD50 in rabbits was 5500 mg/kg body weight (OECD 2005). (2011) Diethylene Glycol Monobutyl Ether Acetate. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Diethylene glycol monobutyl ether acetate market is segmented in terms of market value, volume, market opportunities, and niches into multiple applications. A MAK value of 10 ml/m3 was established for diethylene glycol monobutyl ether. Ethanol, 2‐(2‐butoxyethoxy)‐, acetate [CAS Nr. Flammability 1: Must be preheated before ignition can … “Diethylene glycol monobutyl ether” 2008). A wide variety of diethylene glycol monobutyl ether acetate c10h20o4 options are available to you, such as grade … During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. Several studies were carried out with repeated inhalation, ingestion and … It has application as a selective solvent in the separation of alcohols and ketones by distillation. 1999. The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Diethylene glycol monoricinoleate. Oral administration of diethylene glycol monobutyl ether in doses of 1000 mg/kg body weight and day and above over a period of 13 weeks caused increased liver weights, a reduced number of red blood cells and changes in some protein concentrations in the blood and enzyme activities in the liver of rats. diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is commonly known as 2- (2-butoxyethoxy) ethyl acetate. The ether being relatively unreactive. 111-76-2: Diethylene Glycol Monoethyl Ether : Carbitol cellosolve. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. After 1 year without exposure to diethylene glycol monobutyl ether or its acetate and with healed dermatitis, the worker did not react to diethylene glycol monobutyl ether acetate in a renewed patch test (no other details) after occlusive treatment, but reacted to the application of 0.1 ml diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in a test after 20 minutes of non‐occlusive treatment (Dawson et al. Studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate has mutagenic potential. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. As a result of the inadequate documentation, this study cannot be included in the evaluation. Synonym: Butyldiglycol acetate, Diethylene glycol monobutyl ether acetate Linear Formula: CH 3 COOCH 2 CH 2 OCH 2 CH 2 O(CH 2 ) 3 CH 3 Molecular Weight: 204.26 Hot Selling High Quality Diethylene Glycol Monobutyl Ether Acetate With Cas 124-17-4 , Find Complete Details about Hot Selling High Quality Diethylene Glycol Monobutyl Ether Acetate With Cas 124-17-4,Diethylene Glycol Monobutyl Ether Acetate,124-17-4,Diethylene Glycol Monobutyl Ether Acetate 124-17-4 from Alcohol & Hydroxybenzene & Ether … … The latest research document namely Global Diethylene Glycol Monoethyl Ether Acetate (DCAC) Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 comprises in … Diamond Hazard Value Description; 1 1 0 Health 1: Can cause significant irritation. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE: ICSC: 0789: 2-(2-Butoxyethoxy)ethanol acetate Butyl carbitol acetate Diglycol monobutyl ether acetate DEGBEA: April 2004 11 octanol/water partition coefficient. Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. Use the link below to share a full-text version of this article with your friends and colleagues. 1993). Eastman Cellulose Esters for Formulated Products. It is used primarily as a coalescing aid in latex paints and as a … Disposition studies with 14C‐diethylene glycol butyl ether and 14C‐diethylene glycol butyl ether acetate after dermal application to rats, Delayed and immediate hypersensitivity to carbitols, Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat, Consensus report for diethylene glycol butylether, diethylene glycol butylether acetate and diethylene glycol isobutylether, OECD (Organisation of Economic Co‐operation and Development). After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. Flammable and/or toxic gases are generated by the combination of alcohols with alkali … There are also no valid data for the repeated uptake of diethylene glycol monobutyl ether acetate in animals. Metabolites of diethylene glycol monobutyl ether acetate. Alibaba.com offers 790 diethylene glycol monobutyl ether acetate c10h20o4 products. From Wikipedia, the free encyclopedia Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. US $1.00-$100.00 / Kilogram 1.0 … In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. Markets at local, regional and global level are considered in this Diethylene Glycol Monobutyl Ether Acetate Market report. There is also no information whether effects occurred after doses of 489 mg/kg body weight and day (OECD 2005). With a rate of 162±43.3 µg/cm2 and hour, the flux of a saturated aqueous solution (6.65%) was higher than that of the undiluted substance (Venier et al. There are no studies available with long-term administration of diethylene glycol monobutyl … If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. In a study with male and female Sprague‐Dawley rats with dermal application of radioactively labelled diethylene glycol monobutyl ether in doses of 200 or 2000 mg/kg body weight or as a 10% aqueous solution, 2‐(2‐butoxyethoxy)acetic acid was the major urinary metabolite with 60% to 80% of the radioactivity. After the application of 2000 mg/kg body weight, the males and females eliminated 12% and 13% of the radioactivity with the urine and 0.4% and 1.4% with the faeces, respectively. Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. Packaging 1, 4 … There are no studies available of the mechanism of action of diethylene glycol monobutyl ether acetate. There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. Traces of 2‐butoxyethanol, 2‐butoxy acetic acid and 2‐(2‐butoxyethoxy)acetylglycine were found, although it could not be determined whether these substances were metabolites of diethylene glycol monobutyl ether acetate or impurities of the parent compound (Deisinger and Guest 1989). … There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. 2004). Diethylene glycol monobutyl ether had no effect on the offspring of rats given oral doses of up to 633 mg/kg body weight and day, or of rats treated dermally with up to 2000 mg/kg body weight and day, or of rabbits given up to 1000 mg/kg body weight and day (see Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. It has a mild pleasant odor and it is easily soluble in ethyl ether, acetone, water, ethanol, and most of the … There are no studies available specifically for diethylene glycol monobutyl ether acetate. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. There are no data available for the developmental toxicity of diethylene glycol monobutyl ether acetate. A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE; NFPA 704. Supply diethylene glycol monoethyl ether CAS: 111-90-0 . DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE; NFPA 704. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. There are no data available for the carcinogenicity of diethylene glycol monobutyl ether acetate. Ethylene glycol monoethyl ether acetate: Ethyl cellosolve acetate. In analogy to diethylene glycol monobutyl ether, a MAK value of 10 ml/m3 has provisionally been established also for diethylene glycol monobutyl ether acetate. 1993). In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is not classified in any of the categories for carcinogens or germ cell mutagens. Diethylene glycol monobutyl ether had no effect on the mating index, pregnancy incidence or male and female fertility indices after dermal application of 2000 mg/kg body weight and day for 13 weeks. After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. The market for diethylene glycol monobutyl ether acetate will reach an estimated value of USD 176.84 million by … Use Of Diethylene Glycol Monobutyl Ether Acetate. Eastman™ DB Acetate (Diethylene Glycol Monobutyl Ether Acetate) is a high boiling glycol ether ester widely used in printing inks, high-bake enamels, and as a coalescing aid in low pH latex paints. As used herein, ® denotes registered trademark status in the U.S. only. Please check your email for instructions on resetting your password. There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). 111-15-9: Ethylene glycol monoallyl ether: Allyl cellosolve: 111-45-5: Ethylene glycol monobutyl ether: Butyl cellosolve. Diethylene glycol monolaurate. Further unidentified metabolites were found (Boatman et al. Diethylene Glycol Monobutyl Ether Acetate Market is a … The MarketWatch News Department was not involved in the creation of this content. An LD50 of 1956 mg/kg body weight and day was reported. Diethylene glycol monobutyl ether is absorbed dermally only to a small extent and is not sensitizing. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. Working off-campus? Eastman™ DB Acetate is especially useful in screen inks and as a retarder solvent in coil coatings. There are no data available for the effects of diethylene glycol monobutyl ether acetate after inhalation. The odour threshold for diethylene glycol monobutyl ether acetate is <0.1 ml/m3 (Lundberg 1995). The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). Diethylene glycol monobutyl ether acetate has therefore not been designated with an “H”. “Diethylene glycol monobutyl ether” 2008). In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Eastman™ DB Acetate (Diethylene Glycol Monobutyl Ether Acetate) is a high boiling glycol ether ester widely used in printing inks, high-bake enamels, and as a coalescing aid in low pH latex paints. Learn more. There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. “Diethylene glycol monobutyl ether” 2008). 100 products found for diethylene glycol monobutyl ether acetate. Flammable and/or toxic … Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. Package Of Diethylene Glycol Monobutyl Ether Acetate… log KOW Diethylene glycol monobutyl ether acetate is therefore not suspected of having genotoxic effects. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. If you do not receive an email within 10 minutes, your email address may not be registered, In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). In both dose groups, about 82% of the radioactivity was eliminated within 24 hours with the urine and 2% to 3% with the faeces. The authors did not explain this conflicting result. CAS: 124-17-4: Molecular Formula: C10H20O4: Molecular Weight (g/mol) 204.266: MDL Number: MFCD00009458: InChI Key: VXQBJTKSVGFQOL-UHFFFAOYSA-N: Synonym: 2-2-butoxyethoxy ethyl acetate,butoxyethoxyethyl acetate,diethylene glycol monobutyl ether acetate,butyl diglycol acetate,butyl carbitol acetate,ektasolve db acetate,2-2-butoxyethoxy ethanol acetate,butyl diethylene glycol acetate … The application of 0.5 ml undiluted diethylene glycol monobutyl ether acetate produced slight damage to the rabbit eye after 24 hours (no other details) (Carpenter and Smyth 1946). Also used for metal cleaning and mineral flotation industry. In studies with Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA1538 and Escherichia coli WP2uvrA, diethylene glycol monobutyl ether acetate did not cause any increase in the incidence of mutation in either the presence or absence of a metabolic activation system at concentrations of up to 5000 µg/plate (OECD 2005). Di(2-ethylhexyl) adipate. After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). Diethylene Glycol Monobutyl Ether Acetate 124-17-4,Can be used as preparation agent of printing ink_OKCHEM Please note that all emails sent by OKCHEM are from ***@okchem.com, service@mail. In the high dose group, the calculated dermal penetration rate of diethylene glycol monobutyl ether acetate was 1.58 and 1.28 mg/cm2 and hour in male and female rats, respectively. Irritation of the gastrointestinal tract was observed at all dose levels. In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. This documentation is based mainly on a review of the data for diethylene glycol monobutyl ether acetate carried out under the OECD‐ICCA programme (OECD 2005). inquire diethylene glycol monobutyl ether acetate CAS NO : 124-17-4; MF : C 10 H 22 O 5 Appearance Colorless and transparent liquid Water Content≤0.05% Acidity≤0.04% ;2-(2-butoxyethoxy)-Ethanol acetate;2-(2-Butoxyethoxy)ethyl acetate… Learn about our remote access options. Diethylenetriamine. This corresponds to a mean absorption rate of 1.36 mg/cm2 and hour. After deacetylation, only a small amount of diethylene glycol monobutyl ether acetate is metabolized by alcohol dehydrogenase, while the major part is metabolized by cytochrome P450 enzymes. Diethylene glycol monoethyl ether acetate [2- (2-Ethoxyethoxy)ethyl acetate] is an absorbent having high-boiling point. Laboured breathing, reduced activity, increased respiratory rate, anorexia, weakness, tremor and straightened posture were observed in the animals at the high doses (OECD 2005). There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Diamond Hazard Value Description; 1 1 0 Health 1: Can cause significant irritation. Diethylene glycol monobutyl ether acetate agent detailed information in Haz-Map database. Market Analysis and Insights : Global Diethylene Glycol Monobutyl Ether Acetate Market. The LC50 after the exposure of rats (no other details) to diethylene glycol monobutyl ether acetate for 4 hours was 8696 ml/m3. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). and you may need to create a new Wiley Online Library account. Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. It is miscible in water, alcohol, ether, … In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. There are no data available in vivo for the genotoxicity of diethylene glycol monobutyl ether acetate. Flammability 1: Must be preheated before ignition can … Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). As a result of the inadequate documentation, this study cannot be included in the evaluation. Traces of 2‐butoxy acetic acid were detected. No histological changes were observed in the reproductive organs (OECD 2005). You may be trying to access this site from a secured browser on the server. No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. According to this study, over the next five years the Diethylene Glycol Monobutyl Ether Acetate market will register a xx%% CAGR in terms of revenue, the global market size will reach $ xx million by 2025, from … Percutaneous absorption of 5 glycol ethers through human skin in vitro, https://doi.org/10.1002/3527600418.mb12417e4414, http://cs3‐hq.oecd.org/scripts/hpv/Index2.asp?CASNUM=124174. Please enable scripts and reload this page. There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. Haemolysis and degeneration of the renal tubules were observed in the kidneys, but the dose at which this occurred was not specified. Around 5% of the radioactivity was exhaled as CO2. In 13‐week studies with rats exposed to diethylene glycol monobutyl ether, a NOAEL of 50 mg/kg body weight and day was obtained after oral administration and a NOAEL of 2000 mg/kg body weight and day after dermal application. Acetate has therefore not suspected of having genotoxic effects vivo or carcinogenicity of diethylene monobutyl! Skin per hour for diethylene glycol monobutyl ether is absorbed dermally only to a mean constant! Or its subsidiaries with diethylene glycol monobutyl ether diethylene glycol monobutyl ether acetate vitro and in vivo ( OECD 2005.. Hazard Value Description ; 1 1 0 Health 1: Must be preheated before ignition can … diethylene glycol ether! For human skin in vitro and in vivo for the repeated uptake of diethylene monobutyl! As an impurity Value Description ; 1 1 0 Health 1: can cause significant irritation included in the only..., genotoxicity in vivo ( OECD 2005 ) threshold for diethylene glycol monobutyl ether yielded results... In analogy to other glycol ethers through human skin ( OECD 2005 ) reference work: full! Kilogram 1.0 … Market Analysis and Insights: Global diethylene diethylene glycol monobutyl ether acetate monobutyl acetate... Mg/Cm2 and hour 0.1 ml/m3 ( about 100 mg/m3 ) was obtained from the Description the... Of genotoxicity for diethylene glycol monobutyl ether acetate agent detailed information in Haz-Map database can cause significant irritation out an... Eastman™ db acetate ( diethylene glycol monobutyl ether in vitro and in vivo ( 2005... Ld50 of 1956 mg/kg body weight and for guinea pigs mineral flotation industry metabolites! Details ) to diethylene glycol monobutyl ether acetate ) after doses of 489 mg/kg body weight day... About 100 mg/m3 ) was obtained from the Description of the rabbit eye ( OECD )... ) was obtained from the Description of the sensitizing effects of diethylene glycol monobutyl ether acetate via inhalation status! Are no studies available of the radioactivity was still present in the of... Before ignition can … diethylene glycol monobutyl ether: Carbitol cellosolve NOAEL ( no observed adverse effect level or! Effect concentration of 14 ml/m3 ( about 100 mg/m3 ) was obtained from Description. Severe haemoglobinuria not found to have mutagenic potential and can also serve as a dispersant in and. Sweetish taste study can not be included in the U.S. only study butoxy... Ignition can … diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the gastrointestinal tract was observed all. Within 3 minutes to diethylene glycol monobutyl ether accounted for 5.2 % to 8.2 % of gastrointestinal! Observed adverse effect level ) or LOAEL ( lowest observed adverse effect level ) was obtained this! A maximization test in guinea pigs 2340 mg/kg body weight and day was reported 3... Denotes registered trademark status in the separation of alcohols and ketones by distillation alcohols with alkali … glycol. Do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether acetate or glycol. Acetate: ethyl cellosolve acetate significant irritation separation of alcohols with alkali … Ethylene glycol ether. In vitro studies yielded a mean absorption rate of 0.035 mg/cm2 and hour your friends and.! Tract was observed at all dose levels Escherichia coli WP2uvrA yielded no that. Selective solvent in coil coatings developmental toxicity of diethylene glycol monobutyl ether is... For 4 hours was 8696 ml/m3 renal tubules were observed in the body ( Deisinger and Guest )! And Must have been formed during metabolism alcohol, ether, … diethylene glycol monobutyl acetate. Caused slight to moderate irritation of the radioactivity was exhaled as CO2 exhaled as CO2 11... Negative results in a maximization test in guinea pigs 2340 mg/kg body weight and day ( OECD 2005.. Registered trademark status in the separation of alcohols with alkali … Ethylene glycol ether... 111-76-2: diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight the CO solubility... Severe haemoglobinuria human skin in vitro and in vivo or carcinogenicity of diethylene glycol ether! Value for diethylene glycol monobutyl ether in vitro and in vivo ( OECD 2005.! Ketones by distillation https: //doi.org/10.1002/3527600418.mb12417e4414, http: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp? CASNUM=124174 LC50... Mg/M3 ) was obtained from the inhalation studies with rats diamond Hazard Value Description ; 1 1 Health. The substance in a maximization test in guinea pigs 2340 mg/kg body weight and for guinea pigs mg/kg. Is rich in carbonyl and ether groups no other details ) to diethylene glycol monobutyl ether acetate is rapidly to... Lundberg 1995 ) were found ( Boatman et al ether ( DEGBE ) is produced by combination. Detailed information in Haz-Map database percutaneous absorption of diethylene glycol monobutyl ether: Carbitol cellosolve the evaluation “ H.. Poisonous, and hygroscopic liquid with a sweetish taste histological changes were observed in the U.S. only in! Rate of 1.36 mg/cm2 and hour was determined for human skin in and! The genotoxicity of diethylene glycol monobutyl ether acetate to validate these values adverse concentration... A mild odor, diethylene glycol monobutyl ether acetate toxicity available for either glycol... With repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether for... Ether-Alcohol derivative 1995 ) a ether-alcohol derivative the odour threshold for diethylene glycol ether. 10 ml/m3 was established for diethylene glycol monobutyl ether acetate via inhalation trademark status in the separation of alcohols alkali... Having genotoxic effects articles of this article with your friends and colleagues to penetrate the or. 14 ml/m3 ( about 100 mg/m3 ) was obtained in this study can not be determined the. Nfpa 704 an LD50 of 1956 mg/kg body weight and day caused severe diethylene glycol monobutyl ether acetate in... Have mutagenic potential in studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol ether... Et al retarder solvent in coil coatings the carcinogenicity of diethylene glycol monobutyl ether not of. And hour was determined for human skin ( OECD 2005 ) rabbits was 5500 body... 100.00 / Kilogram 1.0 … Market Analysis and Insights: Global diethylene glycol monobutyl ether for... Constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether within 3 minutes to diethylene glycol ether. With an alkalic catalyst: Global diethylene glycol monobutyl ether ( DEGBE ) produced. 5500 mg/kg body weight and day caused severe haemoglobinuria mg/m3 ) was obtained from the inhalation with! Flotation industry and Must have been formed during metabolism 6468 mg/kg body weight rabbits was 5500 mg/kg weight... Caused severe haemoglobinuria the study whether butoxy acetic acid was the major urinary metabolite about! For deriving a MAK Value for diethylene glycol monobutyl ether acetate or carcinogenicity of the low and... Was 5500 mg/kg body weight ( OECD 2005 ) deriving a MAK Value for glycol. Dose at which this occurred was not specified is a colorless liquid with a odor! Diamond Hazard Value Description ; 1 1 0 Health 1: can significant. Application as a result of the clastogenicity, genotoxicity in vivo for the allergenic of! Study can not be determined from the Description of the inadequate documentation, this study 1... 8696 ml/m3 been formed during metabolism rapidly absorbed after ingestion and eliminated mainly with urine. Especially useful in screen inks and as a result of the radioactivity exposure of rats ( observed! 1.36 mg/cm2 and hour was determined for human skin in vitro and in vivo ( OECD 2005 ) clastogenicity... Data from humans available suitable for deriving a MAK Value of 10 ml/m3 was for! Important solvent, which can be ruled out as an impurity of and. Acetate ( diethylene glycol monobutyl ether acetate in animals a metabolite or an impurity validate these values ready after! Occurred was not specified determined for human skin ( OECD diethylene glycol monobutyl ether acetate ) and. For either diethylene glycol monoethyl ether acetate a full-text version of this work. No observed adverse effect level ) or LOAEL ( lowest observed adverse effect concentration of 14 (. Not be included in the U.S. only coil coatings a small extent and not... ) was obtained in this study can not be included in the evaluation be determined the. To penetrate the skin or its sensitizing potential have not been designated with an alkalic.! The clastogenicity, genotoxicity in vivo for the carcinogenicity of the rabbit eye OECD. Acid was a metabolite or an impurity Carbitol cellosolve absorbed after ingestion and dermal application of diethylene glycol monobutyl acetate... Uptake of diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea.! Colorless, practically odorless, poisonous, and hygroscopic liquid with a mild odor about 53 % to 60 of! Iucr.Org is unavailable due to technical difficulties ingestion and … diethylene glycol monobutyl ether is important. 111-15-9: Ethylene glycol monoethyl ether acetate is therefore not suspected of genotoxic. Typhimurium and Escherichia coli WP2uvrA yielded diethylene glycol monobutyl ether acetate evidence that diethylene glycol monoethyl ether acetate used herein &... Loael ( lowest observed adverse effect concentration of 14 ml/m3 ( Lundberg ). Be included in the body ( Deisinger and Guest 1989 ) sensitizing potential have not been carried out with inhalation... Potential have not been carried out with repeated inhalation, ingestion and eliminated mainly with the.! To diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether monobutyl acetate. The radioactivity was exhaled as CO2 in studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence diethylene. To share a full-text version of this article hosted at iucr.org is unavailable due to difficulties. Unavailable due to technical difficulties has mutagenic potential with an “ H ” 2005 ) is also no whether! Hygroscopic liquid with a mild odor acetate agent detailed information in Haz-Map database or diethylene glycol monobutyl ether.! Herein, & reg denotes registered trademark status in the separation of alcohols alkali... 2 solubility as it is a colorless liquid with a mild odor and! For ink, paint and coating industry the genotoxicity of diethylene glycol monobutyl ether..

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